Natural Product Derivative Libraries
Natural Product Derivative libraries are semi-synthetic collections that utilize validated natural scaffolds (cores) and chemically modify them. These libraries (e.g., from TargetMol, featuring thousands of compounds built on dozens of unique scaffolds) combine the structural complexity of nature with the capabilities of medicinal chemistry, allowing for the optimization of properties such as affinity or solubility. Have you identified a natural product "hit" but need to improve its characteristics through SAR studies, or are you looking for a library with high chemical diversity based on biologically validated cores? Find a derivative library for your lead optimization here.
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Semi-synthetic libraries acting as a bridge between natural substances and medicinal chemistry optimization.
Lead Optimization
- SAR Studies: Testing slight derivative variations to pinpoint active pharmacophores.
- Drug-Likeness: Chemical modifications to improve solubility and metabolic stability.
- Patents: Development of new, patentable molecules based on proven natural scaffolds.
